The rear trailer of a tandem 18-wheeler overturned on the Washington Street ramp to Interstate 20 east around 7:20 a.m. Friday.
The wreck peeled the top off off the trailer, spilling industrial supplies and a sealant onto the roadway and over the guardrail.
No injuries have been reported.
The ramp is closed until cleanup is completed, which could take as long as six hours.
Vicksburg Police Traffic Investigator Russell Dorsey in the lead on the investigation.
See our live, on-the-scene video on our Facebook page.